Zelluläre Neurobiologie - Publikationen

Alves S, Churlaud G, Audrain M, Michaelsen-Preusse K, Fol R, Souchet B, Braudeau J, Korte M, Klatzmann D, Cartier N. (2016) Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice. Brain.

Zagrebelsky, M., Lonnemann, N., Fricke, S., Kellner, Y., Preuss, E., Michaelsen-Preusse, K. & Korte, M. (2016) Nogo-A regulates spatial learning as well as memory formation and modulates structural plasticity in the adult mouse hippocampus. Neurobiol Learn Mem.

Strecker, P., Ludewig, S., Rust, M., Mundinger, T.A., Gorlich, A., Krachan, E.G., Mehrfeld, C., Herz, J., Korte, M., Guenette, S.Y. & Kins, S. (2016) FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation. Sci Rep, 6, 25652.

Michaelsen-Preusse, K., Zessin, S., Grigoryan, G., Scharkowski, F., Feuge, J., Remus, A. & Korte, M. (2016) Neuronal profilins in health and disease: Relevance for spine plasticity and Fragile X syndrome. Proc Natl Acad Sci U S A.

Li, Q., Korte, M. & Sajikumar, S. (2016) Ubiquitin-Proteasome System Inhibition Promotes Long-Term Depression and Synaptic Tagging/Capture. Cereb Cortex, 26, 2541-2548.

Korte, M. & Schmitz, D. (2016) Cellular and System Biology of Memory: Timing, Molecules, and Beyond. Physiol Rev, 96, 647-693.

Kellner, Y., Fricke, S., Kramer, S., Iobbi, C., Wierenga, C.J., Schwab, M.E., Korte, M. & Zagrebelsky, M. (2016) Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics. Hippocampus.

Jaitner, C., Reddy, C., Abentung, A., Whittle, N., Rieder, D., Delekate, A., Korte, M., Jain, G., Fischer, A., Sananbenesi, F., Cera, I., Singewald, N., Dechant, G. & Apostolova, G. (2016) Satb2 determines miRNA expression and long-term memory in the adult central nervous system. eLife, 5.

Iobbi, C., Korte, M. & Zagrebelsky, M. (2016) Nogo-66 Restricts Synaptic Strengthening via Lingo1 and the ROCK2-Cofilin Pathway to Control Actin Dynamics. Cereb Cortex.

Hafi, N., Grunwald, M., van den Heuvel, L.S., Aspelmeier, T., Steinem, C., Korte, M., Munk, A. & Walla, P.J. (2016) Reply to "Polarization modulation adds little additional information to super-resolution fluorescence microscopy". Nature methods, 13, 8-9.

Fol, R., Braudeau, J., Ludewig, S., Abel, T., Weyer, S.W., Roederer, J.P., Brod, F., Audrain, M., Bemelmans, A.P., Buchholz, C.J., Korte, M., Cartier, N. & Muller, U.C. (2016) Viral gene transfer of APPsalpha rescues synaptic failure in an Alzheimer's disease mouse model. Acta neuropathologica, 131, 247-266.

Kurhade C, Zegenhagen L, Weber E, Nair S, Michaelsen-Preusse K, Spanier J, Gekara NO, Kröger A, Överby AK (2016). Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1. J Neuroinflammation. 2016 Jan 27;13:22. doi: 10.1186/s12974-016-0487-9.

Iobbi C, Korte M, Zagrebelsky M (2016) Nogo-66 Restricts Synaptic Strengthening via Lingo1 and the ROCK2-Cofilin Pathway to Control Actin Dynamics. Cereb Cortex. May 10. pii: bhw122

Korte M, Schmitz D (2016) Cellular and system biology of memory: Timing, molecules and beyond. Physiological reviews. DOI: 10.1152/physrev.00010.2015

Michaelsen-Preusse K, Zessin S, Grigoryan G, Scharkowski F, Feuge J, Remus A, Korte M (2016) Neuronal Profilins in Health and Disease: Relevance for Spine Plasticity and Fragile X Syndrome. PNAS doi: 10.1073/pnas.1516697113

Kellner Y, Fricke S, Kramer S, Iobbi C, Wierenga CJ, Schwab ME, Korte M, Zagrebelsky M (2016). Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics. Hippocampus. 2016 Jan 7. doi: 10.1002/hipo.22565.

Hafi N, Grunwald M, van den Heuvel LS, Aspelmeier T, Steinem C, Korte M, Munk A, Walla PJ (2015). Polarization modulation adds little additional information to super-resolution fluorescence microscopy. Nat Methods. 2015 Dec 30;13(1):8-9. doi: 10.1038/nmeth.3721.

Klevanski M, Herrmann U, Weyer SW, Fol R, Cartier N, Wolfer DP, Caldwell JH, Korte M, Müller UC (2015). The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior. J Neurosci. 2015 Dec 9;35(49):16018-33. doi: 10.1523/JNEUROSCI.2009-15.2015.

Fol R Braudeau J, Ludewig S, Abel T, Weyer SW, Roederer JP, Brod F, Audrain M, Bemelmans AP, Buchholz CJ, Korte M, Cartier N, Müller UC (2015).Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model. Acta Neuropathol. 2015 Nov 4.

Burlot MA, Braudeau J, Michaelsen-Preusse K, Potier B, Ayciriex S, Varin J, Gautier B, Djelti F, Audrain M, Dauphinot L, Fernandez-Gomez FJ, Caillierez R, Laprévote O, Bièche I, Auzeil N, Potier MC, Dutar P, Korte M, Buée L, Blum D, Cartier N (2015). Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology. Hum Mol Genet. pii: ddv268.

Chen JH, Kellner Y, Zagrebelsky M, Grunwald M, Korte M, Walla PJ (2015). Two-Photon Correlation Spectroscopy in Single Dendritic Spines Reveals Fast Actin Filament Reorganization during Activity-Dependent Growth. PLoS ONE 10(5):e0128241. doi: 10.1371/journal.pone.0128241

Li Q, Korte M, Sajikumar S (2015) Ubiquitin-Proteasome System Inhibition Promotes Long-Term Depression and Synaptic Tagging/Capture. Cereb Cortex. pii: bhv084.

Monory K, Polack M, Remus A, Lutz B, Korte M (2015) Cannabinoid CB1 receptor calibrates excitatory synaptic balance in the mouse hippocampus. J Neurosci. 4;35(9):3842-50. doi: 10.1523/JNEUROSCI.3167-14.2015.

Schweinhuber SK, Meßerschmidt T, Hänsch R, Korte M, Rothkegel M. (2015). Profilin Isoforms Modulate Astrocytic Morphology and the Motility of Astrocytic Processes. PLoS ONE 10(1):e0117244. doi:10.1371/journal.pone.0117244

Hick M*, Herrmann U*, Weyer SW, Mallm JP, Tschäpe JA, Borgers M, Mercken M, Roth FC, Draguhn A, Slomianka L, Wolfer DP, Korte M*, Müller UC* (2015) Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity. Acta Neuropathol. 129(1):21-37. doi: 10.1007/s00401-014-1368-x. (*equal contribution)

Zagrebelsky M, Korte M (2014) Maintaining stable memory engrams: new roles for Nogo-A in the CNS. Neuroscience. 26;283:17-25. doi: 10.1016/j.neuroscience.2014.08.030.

Sajikumar S, Morris RG, Korte M (2014) Competition between recently potentiated synaptic inputs reveals a winner-take-all phase of synaptic tagging and capture. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1403643111

Hafi N, Grunwald M, Van Den Heuvel LS, Aspelmeier T, Chen JH, Zagrebelsky M, Schutte OM, Steinem C, Korte M, Munk A, Walla PJ (2014) Fluorescence nanoscopy by polarization modulation and polarization angle narrowing. Nat Methods 11,579–584. doi: 10.1038/nmeth.2919.

Kellner Y, Godecke N, Dierkes T, Thieme N, Zagrebelsky M, Korte M (2014) The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity. Front Synaptic Neurosci 6, 5. doi: 10.3389/fnsyn.2014.00005.

Kempf A, Tews B, Arzt ME, Weinmann O, Obermair FJ, Pernet V, Zagrebelsky M, Delekate A, Iobbi C, Zemmar A, Ristic Z, Gullo M, Spies P, Dodd D, Gygax D, Korte M, Schwab ME (2014) The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity. PLoS Biol 12, e1001763. doi: 10.1371/journal.pbio.1001763.

Li Q, Rothkegel M, Xiao ZC, Abraham WC, Korte M, Sajikumar S (2014) Making synapses strong: metaplasticity prolongs associativity of long-term memory by switching synaptic tag mechanisms. Cereb Cortex 24, 353-363. doi: 10.1093/cercor/bhs315.

Nair S, Michaelsen-Preusse K, Finsterbusch K, Stegemann-Koniszewski S, Bruder D, Grashoff M, Korte M, Koster M, Kalinke U, Hauser H, Kroger A (2014) Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons. PLoS Pathog 10, e1003999. doi: 10.1371/journal.ppat.1003999.

Navakkode S, Korte M (2014) Pharmacological activation of CB1 receptor modulates long term potentiation by interfering with protein synthesis. Neuropharmacology 79, 525-533. doi: 10.1016/j.neuropharm.2013.11.018.

Parlog A, Harsan LA, Zagrebelsky M, Weller M, Von Elverfeldt D, Mawrin C, Korte M, Dunay IR (2014) Chronic murine toxoplasmosis is defined by subtle changes in neuronal connectivity. Dis Model Mech 7, 459-469. doi: 10.1242/dmm.014183.

Rowlands DS, Shultz SP, Ogawa T, Aoi W, Korte M (2014) The effects of uniquely-processed titanium on biological systems: implications for human health and performance. J Funct Biomater 5, 1-14. doi: 10.3390/jfb5010001.

Weyer SW, Zagrebelsky M, Herrmann U, Hick M, Ganss L, Gobbert J, Gruber M, Altmann C, Korte M, Deller T, Muller UC (2014) Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsalpha expression. Acta Neuropathol Commun 2, 36. doi: 10.1186/2051-5960-2-36.

Neuser F, Polack M, Annaheim C, Tucker KL, Korte M. (2013) Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit. PLoS One 8(6):e66497.

Zagrebelsky M, Korte M. (2013) Form follows function: BDNF and its involvement in sculpting the function and structure of synapses. Neuropharmacology S0028-3908(13)00243-8.

Zhang X, Herrmann U, Weyer SW, Both M, Müller UC, Korte M, Draguhn A. (2013) Hippocampal network oscillations in APP/APLP2-deficient mice. PLoS One 8(4):e61198.

Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. (2013) NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493:674-678.

Li, Q., Rothkegel, M., Xiao, Z.C., Abraham, W.C., Korte, M. and Sajikumar, S. (2012) Making Synapses Strong: Metaplasticity Prolongs Associativity of Long-Term Memory by Switching Synaptic Tag Mechanisms. Cerebral Cortex, doi: 10.1093/cercor/bhs315.

Navakkode S, Sajikumar S, Korte M, Soong TW. (2012) Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels. Learn Mem. 19(7):294-9.

Korte M, Herrmann U, Zhang X, Draguhn A. (2012) The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models. Exp Brain Res 217(3-4):435-40.

Zhang C, Helmsing S, Zagrebelsky M, Schirrmann T, Marschall AL, Schüngel M, Korte M, Hust M, Dübel S. (2012) Suppression of p75 neurotrophin receptor surface expression with intrabodies influences Bcl-xL mRNA expression and neurite outgrowth in PC12 cells. PLoS One 7(1):e30684.

Murk, K., Wittenmayer, N., Michaelsen-Preusse, K., Dresbach, T., Schoenenberger, C.-A., Korte, M., Jockusch, B.M., and Rothkegel, M. (2012) Neuronal Profilin Isoforms Are Addressed by Different Signalling Pathways. PLoS ONE 7(3): e34167.

Kummer MP, Hermes M, Delekate, A, Hammerschmidt T , Kumar S, Terwel D, Walter J, Pape H-C, König S Roeber S, Jessen F, Klockgether T, Korte M,  Heneka, MT. (2011) Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron 71(5): 833-844.

Delekate A, Zagrebelsky M, Kramer S, Schwab ME, Korte M. (2011) NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale. Proc Natl Acad Sci USA 108:2569-2574.

Navakkode S, Korte M. (2011) Cooperation between cholinergic and glutamatergic receptors are essential to induce BDNF-dependent long-lasting memory storage. Hippocampus 22(2):335-46.

Sajikumar S, Korte M. (2011). Different compartments of apical CA1 dendrites have different plasticity thresholds for expressing synaptic tagging and capture. Learn Mem 18(5):327-331.

Sajikumar S, Korte M. (2011) Metaplasticity governs compartmentalization of synaptic tagging and capture through BDNF and PKMzeta (PKMζ). Proc Natl Acad Sci U S A 108:2551-6.

Weyer SW, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov M, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jaschke A, Korte M, Wolfer DP, Caldwell JH, Muller UC. (2011) APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J 30:2266-2280.

Rauskolb S, Zagrebelsky M, Dreznjak A, Deogracias R, WieseS, Schaeren-Wiemers N, Erne B, Korte M, Barde YA. (2010) Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. J Neurosci 30(5):1739-49.

Zagrebelsky, M., Schweigreiter, R., Bandtlow, C.E., Schwab, M.E., and Korte, M. (2010) Nogo-A stabilizes the architecture of hippocampal neurons. J. Neurosci. 30: 13220-13234.

Michaelsen, K, Murk, K, Zagrebelsky, M, Dreznjak, A, Jockusch, BM, Rothkegel, M and Korte, M. (2010) Fine-tuning of neuronal architecture requires two profilin isoforms. Proc Natl Acad Sci U S A. 107:15780-15785.

Michaelsen, K., Zagrebelsky, M., Berndt-Huch, J., Polack, M., Buschler, A., Sendtner, M., and Korte, M.( 2010) Neurotrophin receptors TrkB.T1 and p75(NTR) cooperate in modulating both functional and structural plasticity in mature hippocampal neurons. Eur. J. Neurosci. 32: 1854-1865.

Sawallisch, C., Berhorster, K., Disanza, A., Mantoani, S., Kintscher, M., Stoenica, L., Dityatev, A., Sieber, S., Kindler, S., Morellini, F., Schweizer, M., Boeckers, T.M., Korte, M., Scita, G., and Kreienkamp, H.J. (2009) The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J. Biol. Chem. 284: 9225-9236.

Korte, M. (2009) Neuroscience. Bridging the gap and staying local. Science 324: 1527-1528.

Korte, M. (2008) Neuroscience. A protoplasmic kiss to remember. Science 319: 1627-1628.

Lahmann I, Fabienke M, Henneberg B, Pabst O, Vauti F, Minge D, Illenberger S, Jockusch BM, Korte M, Arnold HH. (2008) The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticity. Exp Cell Res 314:1048-1060.

Matsumoto T, Rauskolb S, Polack M, Klose J, Kolbeck R, Korte M, Barde YA. (2008) Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat Neurosci 11:131-133.

Schrenk-Siemens K, Perez-Alcala S, Richter J, Lacroix E, Rahuel J, Korte M, Muller U, Barde YA, Bibel M. (2008) Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission. Stem Cells 26:2153-2163.

Papadopoulos T, Korte M, Eulenburg V, Kubota H, Retiounskaia M, Harvey RJ, Harvey K, O'Sullivan GA, Laube B, Hulsmann S, Geiger JR, Betz H. (2007) Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. EMBO J. 26:3888-99.

Deller T, Orth CB, Del TD, Vlachos A, Burbach GJ, Drakew A, Chabanis S, Korte M, Schwegler H, Haas CA, Frotscher M. (2007) A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. Ann Anat 189:5-16.

Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Muller UC. (2007) The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci 27:7817-7826.

Lindecke A, Korte M, Zagrebelsky M, Horejschi V, Elvers M, Widera D, Prullage M, Pfeiffer J, Kaltschmidt B, Kaltschmidt C. (2006) Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1. Eur J Neurosci 24:555-563.

Roth-Alpermann C, Morris RG, Korte M, Bonhoeffer T. (2006) Homeostatic shutdown of long-term potentiation in the adult hippocampus. Proc Natl Acad Sci U S A 103:11039-11044.

Gärtner A, Polnau DG, Staiger V, Sciarretta C, Minichiello L, Thoenen H, Bonhoeffer T, Korte M. (2006) Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling. J Neurosci 26:3496-3504.

Kaltschmidt B, Ndiaye D, Korte M, Pothion S, Arbibe L, Prullage M, Pfeiffer J, Lindecke A, Staiger V, Israel A, Kaltschmidt C, Memet S. (2006) NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling. Mol Cell Biol 26:2936-2946.

Zagrebelsky, M, A. Holz, G. Dechant, Y. A. Barde, T. Bonhoeffer, and Korte, M. (2005) The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons. J. Neurosci. 25 (43):9989-9999.

Rösch*, H, Schweigreiter* G, Barde, Y-A, Bonhoeffer, T, and Korte, M. (2005) Hippocampal long-term depression is impaired in mice lacking the neurotrophin p75 receptor. Proc Natl Acad Sci U S A 102 (20):7362-7367. *equal contribution

Bibel, , M. K. Schrenk, K. L. Tucker, V. Staiger, Korte, M., M. Goetz, and Y. A. Barde (2004) Differentiation of Mouse Embryonic Stem Cells into a Defined Neuronal Lineage. Nat Neurosci 7(9):1003-1009.

Grunwald, IC*, Korte, M* Adelmnann,G, Pueck, A, Kullander, K, Adams, R, Frotscher, M, Bonhoeffer, T, and Klein, R. (2004) Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci 7(1):33-40. *equal contribution

Deller T, Korte M, Chabanis S, Drakew A, Schwegler H, Stefani GG, Zuniga A, Schwarz K, Bonhoeffer T, Zeller R, Frotscher M, Mundel P. (2003) Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci U S A. 100(18):10494-9.

Minichiello, L, Calella, AM, Medina, DL, Bonhoeffer, T, Klein, R, Korte, M. (2002) Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation. Neuron 36: 121-137.

Grunwald, IC*; Korte, M*, Wolfer, D, Wilkinson, GA, Lipp, HP, Bonhoeffer, T, and Klein, R. (2001) Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity and spatial learning. Neuron 32:1027-1040. *equal contribution.

Korte M, Minichiello L, Klein R, Bonhoeffer T. (2000) Shc-binding site in the TrkB receptor is not required for hippocampal long-term potentiation. Neuropharmacology. 39(5):717-24.


Minichiello, L, Korte, M, Wolfer, D, Kühn, R, Unsicker, K, Cestari, V, Rossi-Arnaud, C, Lipp, H P, Bonhoeffer, T, and Klein, R. (1999) Essential role for TrkB receptors in Hippocampus-Mediated Learning. Neuron 24, 401-414.

Korte M, Kang H, Bonhoeffer T, Schuman E. (1998) A role for BDNF in the late-phase of hippocampal long-term potentiation. Neuropharmacology. 37(4-5):553-9.

Griesbeck O, Korte M, Gravel C, Bonhoeffer T, Thoenen H. (1997) Rapid gene transfer into cultured hippocampal neurons and acute hippocampal slices using adenoviral vectors. Brain Res Mol Brain Res. 44(1):171-7.

Korte M, Bonhoeffer T. (1997) Activity-dependent synaptic plasticity: a new face of action for neurotrophins. Mol Psychiatry. 2(3):197-9.


Korte M, Griesbeck O, Gravel C, Carroll P, Staiger V, Thoenen H, Bonhoeffer T. (1996) Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice. Proc Natl Acad Sci USA 93: 12547-12552.

Korte M, Staiger V, Griesbeck O, Thoenen H, Bonhoeffer T. (1996) The involvement of brain-derived neurotrophic factor in hippocampal long-term potentiation revealed by gene targeting experiments. J Physiol Paris. 90(3-4):157-64.

Griesbeck O, Korte M, Staiger V, Gravel C, Carroll P, Bonhoeffer T, Thoenen H. (1996) Combination of gene targeting and gene transfer by adenoviral vectors in the analysis of neurotrophin-mediated neuronal plasticity. Cold Spring Harb Symp Quant Biol. 1996;61:77-83.


Korte M*, Carroll P*, Wolf E, Brem G, Thoenen H, Bonhoeffer T. (1995) Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci USA 92: 8856-8860. *equal contribution.

Rauschecker JP, Korte M. (1993) Auditory compensation for early blindness in cat cerebral cortex. J Neurosci. (10):4538-48.

Korte M, Rauschecker JP. (1993) Auditory spatial tuning of cortical neurons is sharpened in cats with early blindness. J Neurophysiol. 70(4):1717-21.