Dr. Martin Rothkegel 

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  • Phone
    +49 (0)531 3913190
  • Fax
    +49 (0)531 3913222
  • Address
    Technische Universität Braunschweig
    Zoologisches Institut
    Zelluläre Neurobiologie
    Spielmannstr. 7
    38106 Braunschweig, Germany
  • Office
    154
Vita
Name: Martin Rothkegel
Date of birth: 05. July 1960
Academic degrees: Dr. rer. nat.

Academic training and appointments:
1981-1988 Study of Biology TU Braunschweig and University of Bielefeld
1988 Diploma, University of Bielefeld
1989-1993 Doctoral Student at the at the Cell Biology Group of the Department of Developmental Biology, University of Bielefeld
1993 Dr. rer. nat., University of Bielefeld
1993 Akad. Rat at the Zoological Institute, TU Braunschweig
1996-2008
Group Leader Molecular Cell Biology, Zoological Institute, TU Braunschweig
1996–2002 Project Leader in the Collaborative Research Group “Regulation, Modification and Organisation of Structural Proteins” (DFG-Forschergruppe)
2002–2008 Project Leader in the Collaborative Research Group “Regulatory Mechanisms of Cell Differentiation: Determinants of Adhesion and Shape” (DFG-Forschergruppe)
since 2004 Akad. Oberrat at the Zoological Institute, TU Braunschweig
since 2008 Group Leader Cell Biology, Dept. Cellular Neurobiology, TU Braunschweig

Publications

Kaufholdt, D., Baillie, C.-K., Bikker, R., Burkart, V., Dudek, C.-A.,von Pein, L., Rothkegel, M. , Mendel, R.R. and Hänsch, R. (2016). The molybdenum cofactor biosynthesis complex interacts with actin filaments via molybdenum insertase Cnx1 as anchor protein in Arabidopsis thaliana. Plant Sci 244, 8-18. doi:10.1016/j.plantsci.2015.12.011


Schweinhuber, S.K., Meßerschmidt, T., Hänsch, R., Korte, M. and Rothkegel, M. (2015). Profilin Isoforms Modulate Astrocytic Morphology and the Motility of Astrocytic Processes. PLoS ONE 10(1): e0117244. doi:10.1371/journal.pone.0117244

Li, Q., Rothkegel, M., Xiao, Z.C., Abraham, W.C., Korte, M. and Sajikumar, S. (2014) Making Synapses Strong: Metaplasticity Prolongs Associativity of Long-Term Memory by Switching Synaptic Tag Mechanisms. Cerebral Cortex 24, 353-363, doi: 10.1093/cercor/bhs315

Murk, K., Wittenmayer, N., Michaelsen-Preusse, K., Dresbach, T., Schoenenberger, C.-A., Korte, M., Jockusch, B.M., and Rothkegel, M. (2012). Neuronal Profilin Isoforms Are Addressed by Different Signalling Pathways. PLoS ONE 7(3): e34167. doi:10.1371/journal.pone.0034167

Michaelsen, K., Murk, K., Zagrebelsky, M., Dreznjak, A., Jockusch, B.M., Rothkegel, M. and Korte, M. (2010). Fine-tuning of neuronal architecture requires two profilin isoforms. PNAS, doi 10.1073/pnas.1004406107

Wahl, B., Reichmann, D., Niks, D., Krompholz, N., Havemeyer, A., Clement, B., Meßerschmidt, T., Rothkegel, M., Biester, H.,  Hille, R., Mendel, R.R., and Bittner, F. (2010). Biochemical and spectroscopic characterization of the human mitochondrial  amidoxime reducing components hmARC-1 and hm ARC-2 suggests the existence of a new molybdenum-enzyme family in eukaryotes. J. Biol. Chem., doi:10.1074/jbc.M110.169532

Behnen, M., Murk, K., Kursula, P., Cappallo-Obermann, H., Rothkegel, M., Kierszenbaum, A.L. and Kirchhoff, C. (2009). Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids. BMC Cell Biol., 10:34

Murk, K., Buchmeier, S., Jockusch, B.M. and Rothkegel, M. (2009). In birds, profilin-2a is ubiquitously expressed and contributes to actin-based motility. J. Cell Sci. 122, 957-964

Jockusch, B.M., Murk, K. and Rothkegel, M. (2007). The profile of profilin. Rev. Physiol. Biochem. Pharmacol. 159, 131-49

Lederer, M., Jockusch, B. M., and Rothkegel, M. (2005). Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. J. Cell Sci. 118, 331-341

Jockusch, B. M., Rothkegel, M., and Schwarz, G. (2004). Linking the synapse to the cytoskeleton: a breath-taking role for microfilaments. Neuroreport 15, 1535-1538.

Wittenmayer, N., Jandrig, B., Rothkegel, M., Schluter, K., Arnold, W., Haensch, W., Scherneck, S., and Jockusch, B. M. (2004). Tumor suppressor activity of profilin requires a functional actin binding site. Mol Biol Cell 15, 1600-1608

Giesemann, T., Schwarz, G., Nawrotzki, R., Berhorster, K., Rothkegel, M., Schluter, K., Schrader, N., Schindelin, H., Mendel, R. R., Kirsch, J., and Jockusch, B. M. (2003). Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system. J Neurosci 23, 8330-8339

Krebs, A., Rothkegel, M., Klar, M., and Jockusch, B. M. (2001). Characterization of functional domains of mDia1, a link between the small GTPase Rho and the actin cytoskeleton. J Cell Sci 114, 3663-3672

Geese, M., Schluter, K., Rothkegel, M., Jockusch, B. M., Wehland, J., and Sechi, A. S. (2000). Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed. J Cell Sci 113, 1415-1426

Wittenmayer, N., Rothkegel, M., Jockusch, B. M., and Schluter, K. (2000). Functional characterization of green fluorescent protein-profilin fusion proteins. Eur J Biochem 267, 5247-5256

Giesemann, T., Rathke-Hartlieb, S., Rothkegel, M., Bartsch, J. W., Buchmeier, S., Jockusch, B. M., and Jockusch, H. (1999). A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems. J Biol Chem 274, 37908-37914

Rudiger, M., Jockusch, B. M., and Rothkegel, M. (1997). Epitope tag-antibody combination useful for the detection of protein expression in prokaryotic and eukaryotic cells. Biotechniques 23, 96-97.

Schluter, K., Jockusch, B. M., and Rothkegel, M. (1997). Profilins as regulators of actin dynamics. Biochim Biophys Acta 1359, 97-109.

Rothkegel, M., Mayboroda, O., Rohde, M., Wucherpfennig, C., Valenta, R., and Jockusch, B. M. (1996). Plant and animal profilins are functionally equivalent and stabilize microfilaments in living animal cells. J Cell Sci 109, 83-90

Jockusch, B. M., Bubeck, P., Giehl, K., Kroemker, M., Moschner, J., Rothkegel, M., Rudiger, M., Schluter, K., Stanke, G., and Winkler, J. (1995). The molecular architecture of focal adhesions. Ann Rev Cell Dev Biol 11, 379-416.

Giehl, K., Valenta, R., Rothkegel, M., Ronsiek, M., Mannherz, H. G., and Jockusch, B. M. (1994). Interaction of plant profilin with mammalian actin. Eur J Biochem 226, 681-689.