Publications

Originalartikel

A.Kumar, B.Dejanovic, F.Hetsch, M. Semtner, D.Fusca, S.Arjune, JA.Santamaria-Araujo, A.Winkelmann, S.Ayton, A.I.Bush, P.Kloppenburg, J.C.Meier, G.Schwarz & A.A.Belaidi The mechanism of S-sulfocysteine-mediated neurodegeneration in molybdenum cofactor deficiency. Journal of Clinical Investigation 2017; in press, doi: 10.1172/JCI89885.

C.Lorenz, P.Lesimple, P.Bukowiecki, A.Zink, G.Inak, B.Mlody, M.Singh, M.Semtner, N.Mah, K.Auré, M.Leong, O.Zabiegalov, E-M.Lyras, V.Pfiffer, B.Fauler, J.Eichhorst, B.Wiesner, N.Huebner, J.Priller, T.Mielke, D.Meierhofer, Z.Izsvák, J.C.Meier, F.Bouillaud, J.Adjaye, M.Schuelke, E.E.Wanker, A.Lombès & A.Prigione Enabling phenotypic drug discovery for neurological mitochondrial DNA disorders with patient-derived neural progenitor cells. Cell Stem Cell 2017; 20(5): 659-674.e9.

D.Schneidereit, L.Kraus, J.C.Meier, O.Friedrich & D.F.Gilbert Step-by-step guide to building an inexpensive 3D printed motorized positioning stage for automated high-content screening microscopy. Biosensors and Bioelectronics 2017; 92:472-481.

C.Raltschev, F.Hetsch, A.Winkelmann, J.C.Meier* & M.Semtner* (*equal contribution) Electrophysiological signature of homomeric and heteromeric glycine receptor channels. Journal of Biological Chemistry 2016; 291(34):18030-40.

M.Pilorge, C.Fassier, H.Le Corronc, A.Potey, J.Bai, S.De Gois, E.Delaby, B.Assouline, V.Guinchat, F.Devillard, R.Delorme, G.Nygren, M.Rastam, J.C.Meier, S.Otani, H.Cheval, V.M.James, M.Topf, T.N.Dear, C.Gillberg, M.Leboyer, B.Giros, S.Gautron, J.Hazan, R.J.Harvey, P.Legendre & C.Betancur Genetic and functional analyses demonstrate a role for abnormal glycine neurotransmission in autism. Molecular Psychiatry 2016; 21: 936-945.

G.Caliskan, I.Müller, M.Semtner, A.Winkelmann, A.S.Raza, J.O.Hollnagel, A.Rösler, U.Heinemann, O.Stork & J.C.Meier Identification of parvalbumin interneurons as cellular substrate of fear memory persistence. Cerebral Cortex 2016; 26(5): 2325-2340.

B.Dejanovic, T.Djémié, N.Grünewald, A.Suls, V.Kress, F.Hetsch, D.Craiu, M.Zemel, P.Gormley, D.Lal, EuroEPINOMICS Dravet working group, C.T.Myers, H.Mefford, A.Palotie, I.Helbig, J.C.Meier, P.De Jonghe, S.Weckhuysen, G.Schwarz Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy. EMBO Molecular Medicine 2015; 7(12): 1580-1594.

A.Winkelmann, M.Semtner & J.C.Meier Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain. Cell Death & Disease 2015; 6: e1776.

G.Fossati, R.Morini, I.Corradini, F.Antonucci, P.Trepte, E.Edry, V.Sherma, A.Papale, D.Pozzi, P.Defilippi, J.C.Meier, R.Brambilla, E.Turco, K.Rosenblum, E.E.Wanker, N.E.Ziv, E.Menna, M.Matteoli Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis. Cell Death & Differentiation 2015; 22(9):1425-1436.

E.M.Reinthaler, B.Dejanovic, D.Lal, M.Semtner, Y.Merkler, A.Reinhold, D.A.Pittrich, C.Hotzy, M.Feucht, H.Steinböck, U.Gruber-Sedlmayr, G.Ronen, B.Neophytou, J.Geldner, E.Haberlandt, H.Muhle, M.A.Ikram, C.M.van Duijn, A.G.Uitterlinden, A.Hofman, J.Altmüller, A.Kawalia, M.R.Toliat, EuroEPINOMICS Consortium, P.Nürnberg, H.Lerche, M.Nothnagel, H.Thiele, T.Sander, J.C.Meier, G.Schwarz, B.A.Neubauer, F.Zimprich Rare variants in GABAA receptor genes in Rolandic epilepsy and related syndromes. Annals of Neurology 2015; 77(6): 972-986.

A.Winkelmann, X.You, N.Grünewald, U.Häussler, H.Krestel, C.A.Haas, G.Schwarz, W.Chen, J.C.Meier Identification of a new genetic hot spot of evolutionary diversification of protein function. PLoS One 2015; 10(5): e0125413.

J.J.Staudacher, I.S.Naarmann-de Vries, S.J.Ujvari, B.Klinger, M.Kasim, E.Benko, A.Ostareck-Lederer, D.H.Ostareck, A.B.Persson, S.Lorenzen, J.C.Meier, N.Blüthgen, P.B.Persson, A.Henrion-Caude, R.Mrowka, M.Fähling Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmatic reticulum. Nucleic Acids Research 2015; 43: 3219-3236.

M.Kasim, E.Benko, A.Winkelmann, R.Mrowka, J.J.Staudacher, P.B.Persson, H.Scholz, J.C.Meier, M.Fähling Shut down of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia. Journal of Biological Chemistry 2014; 289:26973-26988.

B.Förstera, O.D.a Dzaye, A.Winkelmann, M.Semtner, B.Benedetti, D.S.Markovic, M.Synowitz, P.Wend, M.Fähling, M.-P.Junier, R.Glass, H.Kettenmann, J.C.Meier Intracellular glycine receptor function facilitates glioma formation in vivo. Journal of Cell Science 2014; 127:3687-3698.

B.Dejanovic, M.Semtner, S.Ebert, T.Lamkemeyer, F.Neuser, B.Lüscher, J.C.Meier, G.Schwarz Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses. PLoS Biology 2014; 12(7):e1001908.

K.Notelaers, S.Rocha, R.Paesen, N.Swinnen, J.Vangindertael, J.C.Meier, J.-M.Rigo, M.Ameloot, J.Hofkens Membrane distribution of the glycine receptor alpha3 studied by optical super-resolution microscopy. Histochemistry and Cell Biology 2014; 142:79-90.

A.Winkelmann, N.Maggio, J.Eller, G.Caliskan, M.Semtner, U.Häussler, R.Jüttner, T.Dugladze, B.Smolinsky, S.Kowalczyk, E.Chronowska, G.Schwarz, F.G.Rathjen, G.Rechavi, C.A.Haas, A.Kulik, T.Gloveli, U.Heinemann, J.C.Meier Changes in neural network homeostasis trigger neuropsychiatric symptoms. Journal of Clinical Investigation 2014; 124: 696-711.

K.Notelaers, S.Rocha, R.Paesen, N.Smisdom, B.De Clercq, J.C.Meier, J.-M.Rigo, J.Hofkens, M.Ameloot Analysis of 3 GlyR single particle tracking in the cell membrane. Biochimica et Biophysica Acta - Molecular Cell Research 2014; 1843: 544-553.

T.Dugladze, N.Maziashvili, C.Börgers, S.Gurgenidze, U.Häussler, A.Winkelmann, C.A.Haas, J.C.Meier, I.Vida, N.Kopell, T.Gloveli GABAB autoreceptor-mediated cell-type specific reduction of inhibition in epileptic mice. Proceedings of the National Academy of Sciences 2013; 110:15073-15078.

O.Kletke, O.A.Sergeeva, P.Lorenz, S.Oberland, J.C.Meier, H.Hatt, G.Gisselmann New insights in endogenous modulation of ligand gated ion channels: Histamine is an inverse agonist at strychnine sensitive glycine receptors. European Journal of Pharmacology 2013; 710:59-66.

S.Kowalczyk, A.Winkelmann, B.Smolinsky, B.Förstera, I.Neundorf, G.Schwarz, J.C.Meier Direct binding of GABAA receptor beta2 and beta3 subunits to gephyrin. European Journal of Neuroscience 2013; 37:544-554.

K.Notelaers, N.Smisdom, S.Rocha, D.Janssen, J.C.Meier, J.-M.Rigo, J.Hofkens, M.Ameloot Ensemble and single particle fluorimetric techniques in concerted action to study the diffusion and aggregation of the glycine receptor 3 isoforms in the cell plasma membrane. Biochimica et Biophysica Acta - Biomembranes 2012; 1818:3131-3140.

E.Benko, A.Winkelmann, J.C.Meier, P.B.Persson, H.Scholz, M.Fähling Phorbol-ester mediated suppression of hASH1 synthesis: multiple ways to keep the level down. Frontiers in Molecular Neuroscience 2011; 4:1.

B.Förstera, AA.Belaidi, R.Jüttner, C.Bernert, M.Tsokos, T.-N.Lehmann, P.Horn, G.Schwarz, J.C.Meier Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy. Brain 2010; 133(Pt 12): 3778-3794.

S.A.Eichler, B.Förstera, B.Smolinsky, R.Jüttner, T.-N.Lehmann, G.Schwarz, J.C.Meier Splice-specific roles of glycine receptor alpha3 in the hippocampus. European Journal of Neuroscience 2009; 30(6): 1077-1091.

S.R.Chirasani, D.S.Markovic, M.Synowitz, S.A.Eichler, P.Wisniewski, B.Kaminska, A.Otto, E.Wanker, M.Schäfer, P.Chiarugi, J.C.Meier, H.Kettenmann, R.Glass Transferrin receptor mediated iron accumulation controls proliferation and glutamate release in glioma cells. Journal of Molecular Medicine 2009; 87(2):153-167.

M.Fähling, R.Mrowka, A.Steege, K.M.Kirschner, E.Benko, B.Förstera, P.B.Persson, B.J.Thiele, J.C.Meier, H.Scholz Translational regulation of the human achaete-scute homologue-1 (hASH1) by fragile X-mental retardation protein (FMRP). Journal of Biological Chemistry 2009; 284:4255-4266.

S.A.Eichler, S.Kirischuk, R.Jüttner, P.K.Schäfermeier, P.Legendre, T.-N.Lehmann, T.Gloveli, R.Grantyn, J.C.Meier Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy. Journal of Cellular and Molecular Medicine 2008; 12(6B):2848-2866.

B.Smolinsky, S.A.Eichler, S.Buchmeier, J.C.Meier, G.Schwarz Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis. Journal of Biological Chemistry 2008; 283:17370-17379.

B.Lardi-Studler, B.Smolinsky, C.M.Petitjean, F.Koenig, C.Sidler, J.C.Meier, J.-M.Fritschy, G.Schwarz Vertebrate-specific sequences in gephyrin E-domain regulate cytosolic aggregation and postsynaptic clustering. Journal of Cell Science 2007; 120:1371-1382.

B.Singh, C.Henneberger, D.Betances, M.A.Arevalo, A.Rodriguez-Tebar, J.C.Meier, R.Grantyn Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons. Journal of Neuroscience 2006; 26:7189-7200.

P.Salama-Cohen, M.-A.Arevalo, J.Meier, R.Grantyn, A.Rodríguez-Tébar NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of notch. Molecular Biology of the Cell 2005; 16:339-347.

J.C.Meier, C.Henneberger, I.Melnick, C.Racca, R.J.Harvey, U.Heinemann, V.Schmieden, R.Grantyn RNA editing produces P185L amino acid substitution in glycine receptor alpha3 resulting in high agonist potency. Nature Neuroscience 2005; 8:736-744.

R.Jüttner, M.I.Moré, D.Das, A.Babich, J.Meier, M.Henning, B.Erdmann, E.-C.Müller, A.Otto, R.Grantyn, F.G.Rathjen Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by activity. Neuron 2005; 46:233-245.

C.Henneberger, R.Jüttner, S.A.Schmidt, J.Walter, J.C.Meier, T.Rothe, R.Grantyn GluR- and TrkB-mediated maturation of GABAA receptor function during the period of eye opening. European Journal of Neuroscience 2005; 21:431-440.

J.Meier, R.Grantyn A gephyrin-related mechanism restraining glycine receptor anchoring at GABAergic synapses. Journal of Neuroscience 2004; 24:1398-1405.

J.Meier, R.Grantyn Preferential accumulation of GABAA receptor gamma2L, not gamma2S, cytoplasmic loops at rat spinal cord inhibitory synapses. Journal of Physiology (London) 2004; 559:355-365.

J.Meier, J.Akyeli, S.Kirischuk, R.Grantyn GABAA receptor activity and PKC control inhibitory synaptogenesis in CNS tissue slices. Molecular and Cellular Neuroscience 2003; 23:600-613.

J.Meier, V.Schmieden Inhibition of alpha-subunit glycine receptors by quinoxalines. Neuroreport 2003; 14:1507-1510.

P.Legendre, C.I.Badiu, J.Meier, C.Vannier, A.Triller Desensitization of homomeric alpha1 glycine receptor increases with receptor confinement. Molecular Pharmacology 2002; 62:817-827.

J.Meier, R.Jüttner, S.Kirischuk, R.Grantyn Synaptic anchoring of glycine receptors in developing collicular neurons under control of metabotropic glutamate receptor activity. Molecular and Cellular Neuroscience 2002; 21:324-340.

R.Jüttner, J.Meier, R.Grantyn Slow IPSC kinetics, low levels of apha1 subunit expression and paired-pulse depression are distinct properties of neonatal inhibitory GABAergic synaptic connections in the mouse superior colliculus. European Journal of Neuroscience 2001; 13:2088-98.

J.Meier, C.Vannier, A.Sergé, A.Triller, D.Choquet Fast and reversible trapping of surface glycine receptors by gephyrin. Nature Neuroscience 2001; 4:253-260.

M.Rosenberg, J.Meier, A.Triller, C.Vannier Dynamics of glycine receptor insertion in the neuronal plasma membrane. Journal of Neuroscience 2001; 21:5036-44.

J.Meier, C.Meunier-Durmort, C. Forest, A.Triller, C.Vannier Formation of glycine receptor clusters and their accumulation at synapses. Journal of Cell Science 2000; 113:2783-2795.

J.Meier, M.DeChaldée, A.Triller, C.Vannier Functional heterogeneity of gephyrins. Molecular and Cellular Neuroscience 2000; 16:566-577.

 

 

Übersichtsartikel

J.C.Meier, S.Kankowski, H.Krestel & F.Hetsch RNA editing – Systemic relevance and clue to disease mechanisms? Frontiers in Molecular Neuroscience 2016; 9:124.

J.C.Meier, M.Semtner, A.Winkelmann, J.Wolfart Presynaptic mechanisms of neuronal plasticity and their role in epilepsy. Frontiers in Cellular Neuroscience 2014; 8:164.

R.Grantyn, C.Henneberger, R.Jüttner, J.C.Meier, S.Kirischuk Functional hallmarks of GABAergic synapse maturation and the diverse roles of neurotrophins. Frontiers in Cellular Neuroscience 2011; 5:13.

P.Legendre, B.Förstera, R.Jüttner, J.C.Meier Glycine receptors caught between genome and proteome – Implications of RNA editing and splicing. Frontiers in Molecular Neuroscience 2009; 2:23.

S.A.Eichler & J.C.Meier E-I Balance and human diseases – From molecules to networking. Frontiers in Molecular Neuroscience 2008; 1:2.

J.Meier The enigma of transmitter-selective receptor accumulation at developing inhibitory synapses. Cell and Tissue Research 2003; 311:271-276.

 

Redaktionelle Beiträge

D.Boison, J.C.Meier, S.A.Masino Metabolic control of brain homeostasis. Frontiers in Molecular Neuroscience 2017; 10:184.

J.C.Meier, R.J.Harvey, P.H.Seeburg Frontiers in Molecular Neuroscience – Résumé and perspective. Frontiers in Molecular Neuroscience 2011; 4:58.

W.Wisden, J.C.Meier Genetic techniques and circuit analysis. Frontiers in Molecular Neuroscience 2010; 3:4.

 

Buchbeiträge und Bücher

J.C.Meier, M. Semtner, J. Wolfart Homeostasis of neuronal excitability via synaptic and intrinsic inhibitory mechanisms. In: Homeostatic control of brain function (Boison D & Masino SA, eds), in press. Oxford University Press 2015. ISBN: 9780199322299

Wisden W & Meier JC, eds Genetic techniques and circuit analysis. Frontiers Media SA 2010. E-Book, ISBN: 9782889190263

J.C.Meier Protein kinases and synaptogenesis. In: Molecular Mechanisms of Synaptogenesis (Dityatev A & El-Husseini A, eds), pp 311-332. Springer Press 2006. ISBN: 0387325603

R.Grantyn, R.Jüttner, J.Meier Development and use-dependent modification of synaptic connections in the visual layers of the rodent superior colliculus. In: The superior colliculus, New approaches for studying sensorimotor integration. (Hall WC & Moschovakis A, eds), pp 173-210. CRC Press 2003. ISBN: 0849300975